A new Australian study has looked at nerve cell activity which regulate the flow of ions in and out of cells. This is the first study which has looked at this activity from an ME/CFS perspective.
The ion channels ( TRP channels) were recently called the “key transducers of nociception and pain”. (Neurons associated with the vagus nerve also contain many TRP ion channels.)
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The neurological basis for Fibromyalgia was discussed by Daniel Clauw, M.D., Professor of anesthesiology, University of Michigan at a plenary session address at the American Pain Society Annual Scientific Meeting on May 16 2015. In the US, Fibromyalgia is the second most common rheumatic disorder behind osteoarthritis and, though still widely misunderstood, is now considered to be a lifelong central nervous system disorder, which is responsible for amplified pain that shoots through the body in those who suffer from it. To read the press release please follow the link the prohealth.com.
Results from a recent study published in the journal Arthritis Care & Research indicate that the construct of invalidation as perceived by patients with fibromyalgia includes active negative social responses as well as a lack of positive social responses with respect to the patient and their condition. In this setting, the psychological “construct of invalidation” indicates the perception that a person with fibromyalgia does not really suffer from any real, physical illness.
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Dr Richard Fuller from the Dove Clinic commented on a New Scientist article relating to trials with Rituximab. This is interesting research. It states that some people who underwent treatment for cancer using a monoclonal antibody that blocks CD20 on B cells of the immune system (usually used for lymphoma) could benefit from improved symptoms of underlying chronic fatigue syndrome. The same treatment has also been shown to benefit some people with auto-immune disease. At this stage more work is needed to define why this works. It has long been held that Chronic Fatigue Syndrome relates to a change in immune function which may have knock on effects on the body. If the mechanism can be more clearly defined then approaches that resolve the trigger for the immune response may be discovered rather than relying on medical strategies to suppress immune function, as these inherently cause other health problems.